493.0K XNAS Volume
XNAS 20 Mar, 2025 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Gregory L. Shiferman | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 7.49 per share. | 24 Feb 2025 | 2,502 | 30,759 (0%) | 0% | 7.5 | 18,740 | Common Stock |
| Christopher Benecchi | Chief Operating Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 7.18 per share. | 13 Feb 2025 | 822 | 43,915 (0%) | 0% | 7.2 | 5,902 | Common Stock |
| Laura Gault | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 7.18 per share. | 13 Feb 2025 | 685 | 34,649 (0%) | 0% | 7.2 | 4,918 | Common Stock |
| Gregory L. Shiferman | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 7.18 per share. | 13 Feb 2025 | 251 | 33,261 (0%) | 0% | 7.2 | 1,802 | Common Stock |
| Gregory L. Shiferman | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 7.18 per share. | 13 Feb 2025 | 376 | 33,512 (0%) | 0% | 7.2 | 2,700 | Common Stock |
| Barry E. Greene | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jan 2025 | 174,000 | 174,000 | - | - | Stock Option (Right to Buy) | |
| Christopher Benecchi | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jan 2025 | 20,000 | 44,737 (0%) | 0% | 0 | Common Stock | |
| Christopher Benecchi | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jan 2025 | 40,000 | 40,000 | - | - | Stock Options (Right to buy) | |
| Laura Gault | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jan 2025 | 24,000 | 35,334 (0%) | 0% | 0 | Common Stock | |
| Gregory L. Shiferman | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jan 2025 | 14,000 | 33,888 (0%) | 0% | 0 | Common Stock | |
| Gregory L. Shiferman | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jan 2025 | 28,000 | 28,000 | - | - | Stock Option (Right to buy) | |
| James M. Frates | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2025 | 19,154 | 19,154 | - | - | Stock Options (Right to buy) | |
| George S. Golumbeski | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2025 | 13,593 | 13,593 | - | - | Stock Options (Right to buy) | |
| Gregory L. Shiferman | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 5.48 per share. | 24 Dec 2024 | 79 | 19,888 (0%) | 0% | 5.5 | 433 | Common Stock |
| Gregory L. Shiferman | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Nov 2024 | 5,000 | 19,967 (0%) | 0% | 0 | Common Stock | |
| Gregory L. Shiferman | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Nov 2024 | 10,000 | 10,000 | - | - | Stock Option (Right to buy) | |
| Christopher Benecchi | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Nov 2024 | 12,500 | 12,500 | - | - | Stock Option (Right to buy) | |
| Christopher Benecchi | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Nov 2024 | 6,250 | 24,737 (0%) | 0% | 0 | Common Stock | |
| Barry E. Greene | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Aug 2024 | 50,400 | 97,340 (0%) | 0% | 0 | Common Stock | |
| Barry E. Greene | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.96 per share. | 05 Aug 2024 | 12,273 | 85,067 (0%) | 0% | 9.0 | 109,966 | Common Stock |
| Anne Marie Cook | SVP, GC & Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Aug 2024 | 13,500 | 28,543 (0%) | 0% | 0 | Common Stock | |
| Anne Marie Cook | SVP, GC & Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.96 per share. | 05 Aug 2024 | 4,503 | 24,040 (0%) | 0% | 9.0 | 40,347 | Common Stock |
| Kimi Iguchi | CFO & Treasurer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.96 per share. | 05 Aug 2024 | 3,636 | 81,405 (0%) | 0% | 9.0 | 32,579 | Common Stock |
| Kimi Iguchi | CFO & Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Aug 2024 | 13,500 | 85,041 (0%) | 0% | 0 | Common Stock | |
| Christopher Benecchi | Chief Business Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.96 per share. | 05 Aug 2024 | 4,755 | 18,487 (0%) | 0% | 9.0 | 42,605 | Common Stock |
| Christopher Benecchi | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Aug 2024 | 16,200 | 23,242 (0%) | 0% | 0 | Common Stock | |
| Laura Gault | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.96 per share. | 05 Aug 2024 | 3,288 | 10,737 (0%) | 0% | 9.0 | 29,460 | Common Stock |
| Laura Gault | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Aug 2024 | 13,500 | 14,025 (0%) | 0% | 0 | Common Stock | |
| Jeffrey M. Jonas | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2024 | 12,500 | 12,500 | - | - | Stock Option (Right to Buy) | |
| James M. Frates | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2024 | 12,500 | 12,500 | - | - | Stock Option (Right to Buy) | |
| Geno J. Germano | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2024 | 12,500 | 12,500 | - | - | Stock Option (Right to Buy) | |
| Michael F. Cola | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2024 | 12,500 | 12,500 | - | - | Stock Option (Right to Buy) | |
| George Golumbeski | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2024 | 12,500 | 12,500 | - | - | Stock Option (Right to Buy) | |
| Elizabeth Barrett | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2024 | 12,500 | 12,500 | - | - | Stock Option (Right to Buy) | |
| Jessica J. Federer | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2024 | 12,500 | 12,500 | - | - | Stock Option (Right to Buy) | |
| Christopher Benecchi | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2024 | 13,500 | 19,430 (0%) | 0% | 0 | Common Stock | |
| Christopher Benecchi | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2024 | 27,000 | 27,000 | - | - | Stock Option (Right to Buy) | |
| Anne Marie Cook | SVP, GC & Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2024 | 22,500 | 22,500 | - | - | Stock Option (Right to Buy) | |
| Laura Gault | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2024 | 11,250 | 11,477 (0%) | 0% | 0 | Common Stock | |
| Barry E. Greene | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2024 | 168,000 | 168,000 | - | - | Stock Option (Right to Buy) | |
| Kimi Iguchi | CFO & Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2024 | 11,250 | 81,679 (0%) | 0% | 0 | Common Stock | |
| Laura Gault | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2024 | 22,500 | 22,500 | - | - | Stock Option (Right to Buy) | |
| Marie Anne Cook | SVP, GC & Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2024 | 11,250 | 25,181 (0%) | 0% | 0 | Common Stock | |
| Iguchi Kimi | CFO & Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2024 | 22,500 | 22,500 | - | - | Stock Option (Right to Buy) | |
| M. Steve Paul | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2024 | 3,971 | 3,971 | - | - | Stock Options (Right to buy) | |
| Golumbeski George | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2024 | 3,495 | 3,495 | - | - | Stock Options (Right to buy) | |
| M. Frates James | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2024 | 4,925 | 4,925 | - | - | Stock Options (Right to buy) | |
| J. Jessica Federer | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2024 | 3,177 | 3,177 | - | - | Stock Options (Right to buy) | |
| Kimi Iguchi | CFO & Treasurer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.36 per share. | 02 Jan 2024 | 1,642 | 70,429 (0%) | 0% | 1.4 | 2,233 | Common Stock |
| Kimi Iguchi | CFO & Treasurer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jan 2024 | 1,642 | 0 | - | - | Stock Option (Right to Buy) | |
| Elizabeth Barrett | Director | Purchase of securities on an exchange or from another person at price $ 18.64 per share. | 09 Aug 2023 | 2,000 | 3,000 (0%) | 0% | 18.6 | 37,279 | Common Stock |
| Barry E. Greene | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Aug 2023 | 195,000 | 195,000 | - | - | Stock Option (Right to Buy) | |
| Jeffrey M. Jonas | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2023 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| James M. Frates | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2023 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Steve M. Paul | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2023 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Geno J. Germano | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2023 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Kevin P. Starr | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2023 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Michael F. Cola | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2023 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| George Golumbeski | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2023 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Elizabeth Barrett | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2023 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Jessica J. Federer | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2023 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Elizabeth Barrett | Director | Purchase of securities on an exchange or from another person at price $ 50.50 per share. | 09 May 2023 | 1,000 | 1,000 (0%) | 0% | 50.5 | 50,500 | Common Stock |
| Jessica J. Federer | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Mar 2023 | 19,894 | 19,894 | - | - | Stock Options (Right to buy) | |
| Kimi Iguchi | CFO & Treasurer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2023 | 3,000 | 1,642 | - | - | Stock Option (Right to Buy) | |
| Kimi Iguchi | CFO & Treasurer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.36 per share. | 15 Mar 2023 | 3,000 | 65,560 (0%) | 0% | 1.4 | 4,080 | Common Stock |
| Kimi Iguchi | CFO & Treasurer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.36 per share. | 21 Feb 2023 | 750 | 62,310 (0%) | 0% | 1.4 | 1,020 | Common Stock |
| Kimi Iguchi | CFO & Treasurer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Feb 2023 | 250 | 4,642 | - | - | Stock Option (Right to Buy) | |
| Kimi Iguchi | CFO & Treasurer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Feb 2023 | 750 | 4,892 | - | - | Stock Option (Right to Buy) | |
| Kimi Iguchi | CFO & Treasurer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.36 per share. | 21 Feb 2023 | 250 | 62,560 (0%) | 0% | 1.4 | 340 | Common Stock |
| Barry E. Greene | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2023 | 66,500 | 66,500 | - | - | Stock Option (Right to Buy) | |
| Anne Marie Cook | SVP, GC & Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2023 | 19,000 | 19,000 | - | - | Stock Option (Right to Buy) | |
| Kimi Iguchi | CFO & Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2023 | 16,720 | 16,720 | - | - | Stock Option (Right to Buy) | |
| Albert J. Robichaud | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2023 | 16,720 | 16,720 | - | - | Stock Option (Right to Buy) | |
| Christopher Benecchi | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2023 | 20,900 | 20,900 | - | - | Stock Option (Right to Buy) | |
| Laura Gault | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2023 | 2,660 | 2,660 | - | - | Stock Option (Right to Buy) | |
| Jeffrey M. Jonas | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.45 per share. | 10 Feb 2023 | 11,643 | 133,624 (0%) | 0% | 0.4 | 5,239 | Common Stock |
| Jeffrey M. Jonas | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Feb 2023 | 11,643 | 0 | - | - | Stock Options (Right to buy) | |
| Jeffrey M. Jonas | Director | Sale of securities on an exchange or to another person at price $ 44.90 per share. | 10 Feb 2023 | 3,838 | 121,981 (0%) | 0% | 44.9 | 172,329 | Common Stock |
| Jeffrey M. Jonas | Director | Sale of securities on an exchange or to another person at price $ 44.47 per share. | 10 Feb 2023 | 7,805 | 125,819 (0%) | 0% | 44.5 | 347,084 | Common Stock |
| Anne Marie Cook | SVP, GC & Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 44.16 per share. | 03 Feb 2023 | 980 | 10,498 (0%) | 0% | 44.2 | 43,277 | Common Stock |
| Anne Marie Cook | SVP, GC & Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2023 | 2,850 | 11,478 (0%) | 0% | 0 | Common Stock | |
| Jeffrey M. Jonas | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 44.16 per share. | 03 Feb 2023 | 1,427 | 121,981 (0%) | 0% | 44.2 | 63,016 | Common Stock |
| Jeffrey M. Jonas | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2023 | 5,100 | 123,408 (0%) | 0% | 0 | Common Stock | |
| Kimi Iguchi | CFO & Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2023 | 2,850 | 62,474 (0%) | 0% | 0 | Common Stock | |
| Kimi Iguchi | CFO & Treasurer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 44.16 per share. | 03 Feb 2023 | 914 | 61,560 (0%) | 0% | 44.2 | 40,362 | Common Stock |
| Albert J. Robichaud | Chief Scientific Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 44.16 per share. | 03 Feb 2023 | 1,127 | 145,553 (0%) | 0% | 44.2 | 49,768 | Common Stock |
| Albert J. Robichaud | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2023 | 3,375 | 146,680 (0%) | 0% | 0 | Common Stock | |
| Christopher Benecchi | Chief Business Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 44.16 per share. | 03 Feb 2023 | 2,119 | 5,260 (0%) | 0% | 44.2 | 93,575 | Common Stock |
| Christopher Benecchi | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2023 | 6,750 | 7,379 (0%) | 0% | 0 | Common Stock | |
| Kimi Iguchi | CFO & Treasurer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Jan 2023 | 1,600 | 5,642 | - | - | Stock Option (Right to Buy) | |
| Kimi Iguchi | CFO & Treasurer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.36 per share. | 09 Jan 2023 | 1,600 | 59,624 (0%) | 0% | 1.4 | 2,176 | Common Stock |
| Steve M. Paul | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2023 | 2,395 | 2,395 | - | - | Stock Options (Right to buy) | |
| Kimi Iguchi | CFO & Treasurer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Jan 2023 | 1,800 | 7,242 | - | - | Stock Option (Right to Buy) | |
| Kimi Iguchi | CFO & Treasurer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.36 per share. | 04 Jan 2023 | 1,800 | 58,024 (0%) | 0% | 1.4 | 2,448 | Common Stock |
| George Golumbeski | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2023 | 2,108 | 2,108 | - | - | Stock Options (Right to buy) | |
| Jeffrey M. Jonas | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Jan 2023 | 2,501 | 57,499 | - | - | Stock Option (Right to Buy) | |
| Jeffrey M. Jonas | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 28.63 per share. | 03 Jan 2023 | 2,501 | 118,308 (0%) | 0% | 28.6 | 71,604 | Common Stock |
| Steve M. Paul | Director | Other type of transaction at price $ 38.20 per share. | 28 Nov 2022 | 5 | 78,539 (0%) | 0% | 38.2 | 191 | Common Stock |
| Barry E. Greene | Director, President and CEO | Purchase of securities on an exchange or from another person at price $ 34.48 per share. | 10 Nov 2022 | 14,500 | 46,940 (0%) | 0% | 34.5 | 500,022 | Common Stock |
| Laura Gault | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Nov 2022 | 64,410 | 64,410 | - | - | Stock Option (Right to Buy) | |
| James M. Frates | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2022 | 9,947 | 9,947 | - | - | Stock Option (Right to Buy) | |
| Steve M. Paul | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2022 | 9,947 | 9,947 | - | - | Stock Option (Right to Buy) | |
| Geno J. Germano | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2022 | 9,947 | 9,947 | - | - | Stock Option (Right to Buy) | |
| Kevin P. Starr | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2022 | 9,947 | 9,947 | - | - | Stock Option (Right to Buy) | |
| Michael F. Cola | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2022 | 9,947 | 9,947 | - | - | Stock Option (Right to Buy) | |
| George Golumbeski | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2022 | 9,947 | 9,947 | - | - | Stock Option (Right to Buy) | |
| Elizabeth Barrett | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2022 | 9,947 | 9,947 | - | - | Stock Option (Right to Buy) | |
| Christopher Benecchi | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2022 | 9,500 | 9,500 | - | - | Stock Options (Right to buy) | |
| George Golumbeski | Director | Purchase of securities on an exchange or from another person at price $ 31.45 per share. | 05 May 2022 | 8,000 | 8,000 (0%) | 0% | 31.4 | 251,563 | Common Stock |
| Jeffrey M. Jonas | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Apr 2022 | 30,944 | 11,643 | - | - | Stock Option (Right to Buy) | |
| Jeffrey M. Jonas | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.45 per share. | 27 Apr 2022 | 30,944 | 115,807 (0%) | 0% | 0.5 | 13,925 | Common Stock |
| Jeffrey M. Jonas | Director, Chief Innovation Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.45 per share. | 17 Feb 2022 | 4,000 | 84,863 (0%) | 0% | 0.5 | 1,800 | Common Stock |
| Jeffrey M. Jonas | Director, Chief Innovation Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Feb 2022 | 4,000 | 42,587 | - | - | Stock Option (Right to Buy) | |
| Kimi Iguchi | CFO & Treasurer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.36 per share. | 17 Feb 2022 | 4,500 | 55,600 (0%) | 0% | 1.4 | 6,120 | Common Stock |
| Kimi Iguchi | CFO & Treasurer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Feb 2022 | 4,500 | 9,042 | - | - | Stock Option (Right to Buy) | |
| Barry E. Greene | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Feb 2022 | 69,920 | 69,920 | - | - | Stock Option (Right to Buy) | |
| Anne Marie Cook | SVP, GC & Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Feb 2022 | 15,200 | 15,200 | - | - | Stock Option (Right to Buy) | |
| Jeffrey M. Jonas | Director, Chief Innovation Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Feb 2022 | 15,200 | 15,200 | - | - | Stock Option (Right to Buy) | |
| Kimi Iguchi | CFO & Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Feb 2022 | 15,200 | 15,200 | - | - | Stock Option (Right to Buy) | |
| Albert J. Robichaud | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Feb 2022 | 13,300 | 13,300 | - | - | Stock Option (Right to Buy) | |
| Christopher Benecchi | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Feb 2022 | 11,400 | 11,400 | - | - | Stock Option (Right to Buy) | |
| Steve M. Paul | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2022 | 1,638 | 1,638 | - | - | Stock Options (Right to buy) | |
| George Golumbeski | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2022 | 1,638 | 1,638 | - | - | Stock Options (Right to buy) | |
| Elizabeth Barrett | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2022 | 2,048 | 2,048 | - | - | Stock Options (Right to buy) | |
| Kimi Iguchi | CFO & Treasurer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Nov 2021 | 2,500 | 495 | - | - | Stock Option (Right to Buy) | |
| Kimi Iguchi | CFO & Treasurer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.36 per share. | 22 Nov 2021 | 1,000 | 51,100 (0%) | 0% | 1.4 | 1,360 | Common Stock |
| Kimi Iguchi | CFO & Treasurer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.36 per share. | 22 Nov 2021 | 2,500 | 50,100 (0%) | 0% | 1.4 | 3,400 | Common Stock |
| Kimi Iguchi | CFO & Treasurer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Nov 2021 | 505 | 13,542 | - | - | Stock Option (Right to Buy) | |
| Kimi Iguchi | CFO & Treasurer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Nov 2021 | 495 | 0 | - | - | Stock Option (Right to Buy) | |
| Steven M. Paul | Director | Other type of transaction at price $ 43.00 per share. | 09 Nov 2021 | 1 | 1 (0%) | 0% | 43 | 43 | Common Stock |
| Anne Marie Cook | SVP, GC & Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 40.29 per share. | 19 Oct 2021 | 1,116 | 7,894 (0%) | 0% | 40.3 | 44,964 | Common Stock |
| Anne Marie Cook | SVP, GC & Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Oct 2021 | 3,800 | 9,010 (0%) | 0% | 0 | Common Stock | |
| Jeffrey M. Jonas | Director, Chief Innovation Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 40.29 per share. | 19 Oct 2021 | 4,374 | 80,863 (0%) | 0% | 40.3 | 176,228 | Common Stock |
| Jeffrey M. Jonas | Director, Chief Innovation Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Oct 2021 | 10,000 | 85,237 (0%) | 0% | 0 | Common Stock | |
| Kimi Iguchi | CFO & Treasurer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 40.29 per share. | 19 Oct 2021 | 1,024 | 47,600 (0%) | 0% | 40.3 | 41,257 | Common Stock |
| Kimi Iguchi | CFO & Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Oct 2021 | 3,800 | 48,624 (0%) | 0% | 0 | Common Stock | |
| Stephen J. Kanes | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Oct 2021 | 3,800 | 14,591 (0%) | 0% | 0 | Common Stock | |
| Stephen J. Kanes | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 40.29 per share. | 19 Oct 2021 | 1,120 | 13,471 (0%) | 0% | 40.3 | 45,125 | Common Stock |
| Albert J. Robichaud | Chief Scientific Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 40.29 per share. | 19 Oct 2021 | 1,116 | 142,619 (0%) | 0% | 40.3 | 44,964 | Common Stock |
| Albert J. Robichaud | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Oct 2021 | 3,800 | 143,735 (0%) | 0% | 0 | Common Stock | |
| Christopher Benecchi | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Oct 2021 | 45,000 | 45,000 | - | - | Stock Option (Right to Buy) | |
| Barry E. Greene | Director, President and CEO | Purchase of securities on an exchange or from another person at price $ 43.15 per share. | 05 Aug 2021 | 23,640 | 32,440 (0%) | 0% | 43.1 | 1,020,054 | Common Stock |
| Barry E. Greene | Director, President and CEO | Purchase of securities on an exchange or from another person at price $ 56.32 per share. | 16 Jun 2021 | 8,800 | 8,800 (0%) | 0% | 56.3 | 495,627 | Common Stock |
| James M. Frates | Director | Purchase of securities on an exchange or from another person at price $ 55.10 per share. | 16 Jun 2021 | 1,810 | 1,810 (0%) | 0% | 55.1 | 99,735 | Common Stock |
| Kevin P. Starr | Director | Purchase of securities on an exchange or from another person at price $ 56.05 per share. | 16 Jun 2021 | 17,842 | 320,659 (0%) | 0% | 56.0 | 999,983 | Common Stock |
| Anne Marie Cook | SVP, GC & Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 58.80 per share. | 15 Jun 2021 | 1,144 | 4,973 (0%) | 0% | 58.8 | 67,267 | Common Stock |
| Anne Marie Cook | SVP, GC & Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2021 | 4,000 | 6,117 (0%) | 0% | 0 | Common Stock | |
| Jeffrey M. Jonas | Director, Chief Innovation Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.45 per share. | 15 Jun 2021 | 12,000 | 75,237 (0%) | 0% | 0.5 | 5,400 | Common Stock |
| Jeffrey M. Jonas | Director, Chief Innovation Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2021 | 10,000 | 66,330 (0%) | 0% | 0 | Common Stock | |
| Jeffrey M. Jonas | Director, Chief Innovation Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 58.80 per share. | 15 Jun 2021 | 3,093 | 63,237 (0%) | 0% | 58.8 | 181,868 | Common Stock |
| Jeffrey M. Jonas | Director, Chief Innovation Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jun 2021 | 12,000 | 46,587 | - | - | Stock Option (Right to Buy) | |
| Kimi Iguchi | CFO & Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2021 | 3,500 | 43,355 (0%) | 0% | 0 | Common Stock | |
| Kimi Iguchi | CFO & Treasurer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jun 2021 | 3,000 | 16,047 | - | - | Stock Option (Right to Buy) | |
| Kimi Iguchi | CFO & Treasurer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.36 per share. | 15 Jun 2021 | 2,000 | 44,533 (0%) | 0% | 1.4 | 2,720 | Common Stock |
| Kimi Iguchi | CFO & Treasurer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 58.80 per share. | 15 Jun 2021 | 822 | 42,533 (0%) | 0% | 58.8 | 48,334 | Common Stock |
| Kimi Iguchi | CFO & Treasurer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.36 per share. | 15 Jun 2021 | 3,000 | 39,855 (0%) | 0% | 1.4 | 4,080 | Common Stock |
| Kimi Iguchi | CFO & Treasurer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jun 2021 | 2,000 | 14,047 | - | - | Stock Option (Right to Buy) | |
| Stephen J. Kanes | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 58.80 per share. | 15 Jun 2021 | 1,001 | 10,791 (0%) | 0% | 58.8 | 58,859 | Common Stock |
| Stephen J. Kanes | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2021 | 3,500 | 11,792 (0%) | 0% | 0 | Common Stock | |
| Albert J. Robichaud | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2021 | 4,000 | 140,795 (0%) | 0% | 0 | Common Stock | |
| Albert J. Robichaud | Chief Scientific Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 58.80 per share. | 15 Jun 2021 | 1,144 | 139,651 (0%) | 0% | 58.8 | 67,267 | Common Stock |
| James M. Frates | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2021 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Steven M. Paul | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2021 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Geno J. Germano | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2021 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Kevin P. Starr | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2021 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Michael F. Cola | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2021 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| George Golumbeski | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2021 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Elizabeth Barrett | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2021 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Kimi Iguchi | CFO & Treasurer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.36 per share. | 13 Apr 2021 | 1,500 | 36,855 (0%) | 0% | 1.4 | 2,040 | Common Stock |
| Kimi Iguchi | CFO & Treasurer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Apr 2021 | 948 | 0 | - | - | Stock Option (Right to Buy) | |
| Kimi Iguchi | CFO & Treasurer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Apr 2021 | 552 | 2,995 | - | - | Stock Option (Right to Buy) | |
| Anne Marie Cook | SVP, GC & Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Feb 2021 | 19,000 | 19,000 | - | - | Stock Option (Right to Buy) | |
| Jeffrey M. Jonas | Director, Chief Innovation Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Feb 2021 | 34,000 | 34,000 | - | - | Stock Option (Right to Buy) | |
| Kimi Iguchi | CFO & Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Feb 2021 | 19,000 | 19,000 | - | - | Stock Option (Right to Buy) | |
| Stephen J. Kanes | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Feb 2021 | 19,000 | 19,000 | - | - | Stock Option (Right to Buy) | |
| Albert J. Robichaud | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Feb 2021 | 22,500 | 22,500 | - | - | Stock Option (Right to Buy) | |
| Michael Cloonan | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Feb 2021 | 19,000 | 19,000 | - | - | Stock Option (Right to Buy) | |
| Jeffrey M. Jonas | Director, Chief Innovation Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Jan 2021 | 1,800 | 58,587 | - | - | Stock Option (Right to Buy) | |
| Jeffrey M. Jonas | Director, Chief Innovation Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.45 per share. | 27 Jan 2021 | 1,800 | 56,330 (0%) | 0% | 0.5 | 810 | Common Stock |
| Kimi Iguchi | CFO & Treasurer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.36 per share. | 05 Jan 2021 | 1,750 | 35,355 (0%) | 0% | 1.4 | 2,380 | Common Stock |
| Kimi Iguchi | CFO & Treasurer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jan 2021 | 1,750 | 948 | - | - | Stock Option (Right to Buy) | |
| George Golumbeski | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jan 2021 | 832 | 832 | - | - | Stock Options (Right to buy) | |
| Elizabeth Barrett | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jan 2021 | 915 | 915 | - | - | Stock Options (Right to buy) | |
| Barry E. Greene | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2021 | 390,000 | 390,000 | - | - | Stock Options (Right to buy) | |
| James M. Frates | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2020 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Steven M. Paul | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2020 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Geno J. Germano | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2020 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Kevin P. Starr | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2020 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Michael F. Cola | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2020 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| George Golumbeski | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2020 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Elizabeth Barrett | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2020 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Michael Cloonan | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 May 2020 | 50,000 | 50,000 | - | - | Stock Option (Right to Buy) | |
| Kimi Iguchi | CFO & Treasurer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Apr 2020 | 4,000 | 2,698 | - | - | Stock Option (Right to Buy) | |
| Kimi Iguchi | CFO & Treasurer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.36 per share. | 30 Apr 2020 | 4,000 | 33,261 (0%) | 0% | 1.4 | 5,440 | Common Stock |
| Anne Marie Cook | SVP, GC & Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Apr 2020 | 9,450 | 9,450 | - | - | Stock Option (Right to Buy) | |
| Jeffrey M. Jonas | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Apr 2020 | 15,385 | 15,385 | - | - | Stock Option (Right to Buy) | |
| Kimi Iguchi | CFO & Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Apr 2020 | 9,450 | 9,450 | - | - | Stock Option (Right to Buy) | |
| Stephen J. Kanes | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Apr 2020 | 9,450 | 9,450 | - | - | Stock Option (Right to Buy) | |
| Albert J. Robichaud | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Apr 2020 | 9,450 | 9,450 | - | - | Stock Option (Right to Buy) | |
| Michael Cloonan | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Apr 2020 | 9,450 | 9,450 | - | - | Stock Option (Right to Buy) | |
| Anne Marie Cook | SVP, GC & Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Feb 2020 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Jeffrey M. Jonas | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Feb 2020 | 50,000 | 50,000 | - | - | Stock Option (Right to Buy) | |
| Kimi Iguchi | CFO & Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Feb 2020 | 17,500 | 17,500 | - | - | Stock Option (Right to Buy) | |
| Stephen J. Kanes | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Feb 2020 | 17,500 | 17,500 | - | - | Stock Option (Right to Buy) | |
| Albert J. Robichaud | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Feb 2020 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Michael Cloonan | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Feb 2020 | 22,500 | 22,500 | - | - | Stock Option (Right to Buy) | |
| George Golumbeski | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2020 | 976 | 976 | - | - | Stock Options (Right to buy) | |
| Jeffrey M. Jonas | Director, President & CEO | Purchase of securities on an exchange or from another person at price $ 64.20 per share. | 09 Dec 2019 | 7,500 | 54,530 (0%) | 0% | 64.2 | 481,500 | Common Stock |
| Kimi Iguchi | CFO & Treasurer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Dec 2019 | 500 | 3,547 | - | - | Stock Option (Right to Buy) | |
| Kimi Iguchi | CFO & Treasurer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Dec 2019 | 15,000 | 4,047 | - | - | Stock Option (Right to Buy) | |
| Kimi Iguchi | CFO & Treasurer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.36 per share. | 09 Dec 2019 | 500 | 29,261 (0%) | 0% | 1.4 | 680 | Common Stock |
| Kimi Iguchi | CFO & Treasurer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.36 per share. | 09 Dec 2019 | 15,000 | 28,761 (0%) | 0% | 1.4 | 20,400 | Common Stock |
| Albert J. Robichaud | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Dec 2019 | 3,076 | 21,924 | - | - | Stock Option (Right to Buy) | |
| Albert J. Robichaud | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Dec 2019 | 5,732 | 32,668 | - | - | Stock Option (Right to Buy) | |
| Albert J. Robichaud | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Dec 2019 | 6,935 | 0 | - | - | Stock Option (Right to Buy) | |
| Albert J. Robichaud | Chief Scientific Officer | Purchase of securities on an exchange or from another person at price $ 64.16 per share. | 09 Dec 2019 | 25,000 | 136,400 (0%) | 0% | 64.2 | 1,604,000 | Common Stock |
| Albert J. Robichaud | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 28.63 per share. | 09 Dec 2019 | 3,076 | 111,400 (0%) | 0% | 28.6 | 88,066 | Common Stock |
| Albert J. Robichaud | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.25 per share. | 09 Dec 2019 | 5,732 | 108,324 (0%) | 0% | 38.3 | 219,249 | Common Stock |
| Albert J. Robichaud | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.36 per share. | 09 Dec 2019 | 6,935 | 102,592 (0%) | 0% | 1.4 | 9,432 | Common Stock |
| Jeffrey M. Jonas | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Sep 2019 | 4,600 | 60,387 | - | - | Stock Option (Right to Buy) | |
| Jeffrey M. Jonas | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.45 per share. | 11 Sep 2019 | 4,600 | 47,030 (0%) | 0% | 0.5 | 2,070 | Common Stock |
| Stephen J. Kanes | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Sep 2019 | 6,000 | 86,100 | - | - | Stock Option (Right to Buy) | |
| Stephen J. Kanes | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.45 per share. | 04 Sep 2019 | 6,000 | 8,292 (0%) | 0% | 0.5 | 2,700 | Common Stock |
| James M. Frates | None | Gift of securities by or to the insider at price $ 0.00 per share. | 15 Aug 2019 | 500 | 2,535 (0%) | 0% | 0 | Common Stock | |
| James M. Frates | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Aug 2019 | 8,000 | 5,922 | - | - | Stock Option (Right to Buy) | |
| James M. Frates | None | Sale of securities on an exchange or to another person at price $ 160.58 per share. | 15 Aug 2019 | 8,000 | 2,535 (0%) | 0% | 160.6 | 1,284,640 | Common Stock |
| James M. Frates | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 28.35 per share. | 15 Aug 2019 | 8,000 | 10,535 (0%) | 0% | 28.4 | 226,800 | Common Stock |
| James M. Frates | None | Gift of securities by or to the insider at price $ 0.00 per share. | 15 Aug 2019 | 1,200 | 3,035 (0%) | 0% | 0 | Common Stock | |
| Anne Marie Cook | SVP, GC & Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 161.38 per share. | 25 Jul 2019 | 844 | 1,756 (0%) | 0% | 161.4 | 136,205 | Common Stock |
| Anne Marie Cook | SVP, GC & Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Jul 2019 | 1,900 | 2,600 (0%) | 0% | 0 | Common Stock | |
| Jeffrey M. Jonas | Director, President & CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 161.38 per share. | 25 Jul 2019 | 1,685 | 42,430 (0%) | 0% | 161.4 | 271,925 | Common Stock |
| Jeffrey M. Jonas | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Jul 2019 | 5,000 | 44,115 (0%) | 0% | 0 | Common Stock | |
| Kimi Iguchi | CFO & Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Jul 2019 | 1,900 | 14,309 (0%) | 0% | 0 | Common Stock | |
| Kimi Iguchi | CFO & Treasurer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 161.38 per share. | 25 Jul 2019 | 548 | 13,761 (0%) | 0% | 161.4 | 88,436 | Common Stock |
| Kimi Iguchi | CFO & Treasurer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Jul 2019 | 2,000 | 6,698 | - | - | Stock Option (Right to Buy) | |
| Kimi Iguchi | CFO & Treasurer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.36 per share. | 25 Jul 2019 | 2,000 | 12,409 (0%) | 0% | 1.4 | 2,720 | Common Stock |
| Stephen J. Kanes | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Jul 2019 | 1,900 | 2,841 (0%) | 0% | 0 | Common Stock | |
| Stephen J. Kanes | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 161.38 per share. | 25 Jul 2019 | 549 | 2,292 (0%) | 0% | 161.4 | 88,598 | Common Stock |
| Albert J. Robichaud | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Jul 2019 | 1,900 | 96,205 (0%) | 0% | 0 | Common Stock | |
| Albert J. Robichaud | Chief Scientific Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 25 Jul 2019 | 825 | 94,137 (0%) | 0% | 0 | Common Stock | |
| Albert J. Robichaud | Chief Scientific Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 161.38 per share. | 25 Jul 2019 | 548 | 95,657 (0%) | 0% | 161.4 | 88,436 | Common Stock |
| Michael Cloonan | Chief Business Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 161.38 per share. | 25 Jul 2019 | 1,088 | 2,102 (0%) | 0% | 161.4 | 175,581 | Common Stock |
| Michael Cloonan | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Jul 2019 | 2,450 | 3,190 (0%) | 0% | 0 | Common Stock | |
| Kimi Iguchi | CFO & Treasurer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jul 2019 | 4,000 | 8,698 | - | - | Stock Option (Right to Buy) | |
| Kimi Iguchi | CFO & Treasurer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.36 per share. | 17 Jul 2019 | 4,000 | 10,409 (0%) | 0% | 1.4 | 5,440 | Common Stock |
| Jeffrey M. Jonas | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jul 2019 | 27,000 | 64,987 | - | - | Stock Option (Right to Buy) | |
| Jeffrey M. Jonas | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.45 per share. | 16 Jul 2019 | 27,000 | 39,115 (0%) | 0% | 0.5 | 12,150 | Common Stock |
| Anne Marie Cook | SVP, GC & Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jun 2019 | 9,240 | 18,480 | - | - | Stock Option (Right to Buy) | |
| Jeffrey M. Jonas | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jun 2019 | 23,100 | 46,200 | - | - | Stock Option (Right to Buy) | |
| Kimi Iguchi | CFO & Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jun 2019 | 7,425 | 14,850 | - | - | Stock Option (Right to Buy) | |
| Stephen J. Kanes | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jun 2019 | 6,600 | 13,200 | - | - | Stock Option (Right to Buy) | |
| Albert J. Robichaud | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jun 2019 | 6,600 | 13,200 | - | - | Stock Option (Right to Buy) | |
| James M. Frates | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2019 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Steven M. Paul | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2019 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Geno J. Germano | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2019 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Kevin P. Starr | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2019 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Michael F. Cola | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2019 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| George Golumbeski | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2019 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Asha Nayak | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2019 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Elizabeth Barrett | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2019 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Jeffrey M. Jonas | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 171.01 per share. | 23 May 2019 | 500 | 115,523 (0%) | 0% | 171.0 | 85,505 | Common Stock |
| Jeffrey M. Jonas | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.45 per share. | 23 May 2019 | 53,908 | 116,023 (0%) | 0% | 0.5 | 24,259 | Common Stock |
| Jeffrey M. Jonas | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 172.20 per share. | 23 May 2019 | 1,619 | 113,904 (0%) | 0% | 172.2 | 278,792 | Common Stock |
| Jeffrey M. Jonas | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 173.41 per share. | 23 May 2019 | 4,200 | 109,704 (0%) | 0% | 173.4 | 728,322 | Common Stock |
| Jeffrey M. Jonas | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 174.46 per share. | 23 May 2019 | 31,099 | 78,605 (0%) | 0% | 174.5 | 5,425,532 | Common Stock |
| Jeffrey M. Jonas | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 175.09 per share. | 23 May 2019 | 14,727 | 63,878 (0%) | 0% | 175.1 | 2,578,550 | Common Stock |
| Jeffrey M. Jonas | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 176.15 per share. | 23 May 2019 | 1,763 | 62,115 (0%) | 0% | 176.1 | 310,552 | Common Stock |
| Jeffrey M. Jonas | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.45 per share. | 23 May 2019 | 40,356 | 102,471 (0%) | 0% | 0.4 | 18,160 | Common Stock |
| Jeffrey M. Jonas | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 174.05 per share. | 23 May 2019 | 7,948 | 94,523 (0%) | 0% | 174.0 | 1,383,349 | Common Stock |
| Jeffrey M. Jonas | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 175.02 per share. | 23 May 2019 | 24,966 | 69,557 (0%) | 0% | 175.0 | 4,369,549 | Common Stock |
| Jeffrey M. Jonas | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 175.79 per share. | 23 May 2019 | 3,974 | 65,583 (0%) | 0% | 175.8 | 698,589 | Common Stock |
| Jeffrey M. Jonas | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 176.80 per share. | 23 May 2019 | 2,518 | 63,065 (0%) | 0% | 176.8 | 445,182 | Common Stock |
| Jeffrey M. Jonas | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 177.76 per share. | 23 May 2019 | 950 | 62,115 (0%) | 0% | 177.8 | 168,872 | Common Stock |
| Jeffrey M. Jonas | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 May 2019 | 53,908 | 168,079 | - | - | Stock Option (Right to Buy) | |
| Jeffrey M. Jonas | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 May 2019 | 40,356 | 127,723 | - | - | Stock Option (Right to Buy) | |
| Michael Cloonan | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 175.00 per share. | 22 May 2019 | 25,000 | 461 (0%) | 0% | 175 | 4,375,000 | Common Stock |
| Michael Cloonan | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 73.43 per share. | 22 May 2019 | 25,000 | 25,461 (0%) | 0% | 73.4 | 1,835,750 | Common Stock |
| Michael Cloonan | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 May 2019 | 25,000 | 160,000 | - | - | Stock Option (Right to Buy) | |
| Anne Marie Cook | SVP, GC & Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 56.27 per share. | 10 May 2019 | 700 | 700 (0%) | 0% | 56.3 | 39,389 | Common Stock |
| Anne Marie Cook | SVP, GC & Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 28.63 per share. | 10 May 2019 | 15,000 | 15,000 (0%) | 0% | 28.6 | 429,450 | Common Stock |
| Anne Marie Cook | SVP, GC & Secretary | Sale of securities on an exchange or to another person at price $ 166.14 per share. | 10 May 2019 | 15,000 | 0 (0%) | 0% | 166.1 | 2,492,100 | Common Stock |
| Anne Marie Cook | SVP, GC & Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 May 2019 | 700 | 109,300 | - | - | Stock Option (Right to Buy) | |
| Anne Marie Cook | SVP, GC & Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 May 2019 | 15,000 | 15,000 | - | - | Stock Option (Right to Buy) | |
| Steven M. Paul | None | Sale of securities on an exchange or to another person at price $ 161.04 per share. | 21 Mar 2019 | 2,993 | 127,286 (0%) | 0% | 161.0 | 481,993 | Common Stock |
| Steven M. Paul | None | Sale of securities on an exchange or to another person at price $ 161.02 per share. | 21 Mar 2019 | 1,967 | 122,400 (0%) | 0% | 161.0 | 316,726 | Common Stock |
| Steven M. Paul | None | Sale of securities on an exchange or to another person at price $ 161.05 per share. | 21 Mar 2019 | 2,919 | 124,367 (0%) | 0% | 161.1 | 470,105 | Common Stock |
| Steven M. Paul | None | Sale of securities on an exchange or to another person at price $ 161.01 per share. | 18 Mar 2019 | 900 | 189,800 (0%) | 0% | 161.0 | 144,909 | Common Stock |
| Steven M. Paul | None | Sale of securities on an exchange or to another person at price $ 161.35 per share. | 18 Mar 2019 | 13,047 | 130,279 (0%) | 0% | 161.3 | 2,105,133 | Common Stock |
| Steven M. Paul | None | Sale of securities on an exchange or to another person at price $ 161.32 per share. | 18 Mar 2019 | 13,096 | 143,326 (0%) | 0% | 161.3 | 2,112,647 | Common Stock |
| Steven M. Paul | None | Sale of securities on an exchange or to another person at price $ 161.20 per share. | 18 Mar 2019 | 16,182 | 156,422 (0%) | 0% | 161.2 | 2,608,538 | Common Stock |
| Steven M. Paul | None | Sale of securities on an exchange or to another person at price $ 161.32 per share. | 18 Mar 2019 | 14,321 | 172,604 (0%) | 0% | 161.3 | 2,310,264 | Common Stock |
| Steven M. Paul | None | Sale of securities on an exchange or to another person at price $ 161.01 per share. | 18 Mar 2019 | 875 | 186,925 (0%) | 0% | 161.0 | 140,884 | Common Stock |
| Steven M. Paul | None | Sale of securities on an exchange or to another person at price $ 161.02 per share. | 18 Mar 2019 | 800 | 187,800 (0%) | 0% | 161.0 | 128,816 | Common Stock |
| Steven M. Paul | None | Sale of securities on an exchange or to another person at price $ 161.14 per share. | 18 Mar 2019 | 1,200 | 188,600 (0%) | 0% | 161.1 | 193,368 | Common Stock |
| Kimi Iguchi | CFO & Treasurer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Mar 2019 | 4,723 | 0 | - | - | Stock Option (Right to Buy) | |
| Kimi Iguchi | CFO & Treasurer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.45 per share. | 08 Mar 2019 | 4,723 | 6,136 (0%) | 0% | 0.4 | 2,125 | Common Stock |
| Steven M. Paul | None | Sale of securities on an exchange or to another person at price $ 161.00 per share. | 01 Mar 2019 | 700 | 190,700 (0%) | 0% | 161 | 112,700 | Common Stock |
| Steven M. Paul | None | Sale of securities on an exchange or to another person at price $ 161.00 per share. | 01 Mar 2019 | 700 | 191,400 (0%) | 0% | 161 | 112,700 | Common Stock |
| Steven M. Paul | None | Sale of securities on an exchange or to another person at price $ 161.00 per share. | 01 Mar 2019 | 500 | 192,100 (0%) | 0% | 161 | 80,500 | Common Stock |
| Steven M. Paul | None | Sale of securities on an exchange or to another person at price $ 161.00 per share. | 01 Mar 2019 | 700 | 192,600 (0%) | 0% | 161 | 112,700 | Common Stock |
| Kimi Iguchi | CFO & Treasurer | Sale of securities on an exchange or to another person at price $ 156.93 per share. | 01 Mar 2019 | 25,563 | 1,413 (0%) | 0% | 156.9 | 4,011,602 | Common Stock |
| Steven M. Paul | None | Sale of securities on an exchange or to another person at price $ 161.00 per share. | 25 Feb 2019 | 500 | 72,400 (0%) | 0% | 161 | 80,500 | Common Stock |
| Steven M. Paul | None | Gift of securities by or to the insider at price $ 0.00 per share. | 25 Feb 2019 | 30,600 | 193,300 (0%) | 0% | 0 | Common Stock | |
| Steven M. Paul | None | Gift of securities by or to the insider at price $ 0.00 per share. | 25 Feb 2019 | 30,600 | 162,700 (0%) | 0% | 0 | Common Stock | |
| Steven M. Paul | None | Gift of securities by or to the insider at price $ 0.00 per share. | 25 Feb 2019 | 30,600 | 132,100 (0%) | 0% | 0 | Common Stock | |
| Steven M. Paul | None | Gift of securities by or to the insider at price $ 0.00 per share. | 25 Feb 2019 | 30,600 | 101,500 (0%) | 0% | 0 | Common Stock | |
| Steven M. Paul | None | Gift of securities by or to the insider at price $ 0.00 per share. | 25 Feb 2019 | 122,400 | 119,295 (0%) | 0% | 0 | Common Stock | |
| Steven M. Paul | None | Sale of securities on an exchange or to another person at price $ 161.00 per share. | 25 Feb 2019 | 500 | 70,900 (0%) | 0% | 161 | 80,500 | Common Stock |
| Steven M. Paul | None | Sale of securities on an exchange or to another person at price $ 161.00 per share. | 25 Feb 2019 | 500 | 71,400 (0%) | 0% | 161 | 80,500 | Common Stock |
| Steven M. Paul | None | Sale of securities on an exchange or to another person at price $ 161.00 per share. | 25 Feb 2019 | 500 | 71,900 (0%) | 0% | 161 | 80,500 | Common Stock |
| Steven M. Paul | None | Gift of securities by or to the insider at price $ 0.00 per share. | 15 Feb 2019 | 241,695 | 272,777 (0%) | 0% | 0 | Common Stock | |
| Steven M. Paul | None | Sale of securities on an exchange or to another person at price $ 162.00 per share. | 15 Feb 2019 | 200 | 72,900 (0%) | 0% | 162 | 32,400 | Common Stock |
| Steven M. Paul | None | Sale of securities on an exchange or to another person at price $ 161.37 per share. | 15 Feb 2019 | 643 | 73,100 (0%) | 0% | 161.4 | 103,761 | Common Stock |
| Steven M. Paul | None | Sale of securities on an exchange or to another person at price $ 161.62 per share. | 15 Feb 2019 | 500 | 73,743 (0%) | 0% | 161.6 | 80,812 | Common Stock |
| Steven M. Paul | None | Sale of securities on an exchange or to another person at price $ 162.00 per share. | 15 Feb 2019 | 200 | 74,243 (0%) | 0% | 162 | 32,400 | Common Stock |
| Steven M. Paul | None | Sale of securities on an exchange or to another person at price $ 161.02 per share. | 15 Feb 2019 | 12,388 | 74,443 (0%) | 0% | 161.0 | 1,994,716 | Common Stock |
| Steven M. Paul | None | Sale of securities on an exchange or to another person at price $ 161.02 per share. | 15 Feb 2019 | 12,044 | 86,831 (0%) | 0% | 161.0 | 1,939,325 | Common Stock |
| Steven M. Paul | None | Sale of securities on an exchange or to another person at price $ 161.02 per share. | 15 Feb 2019 | 12,510 | 98,875 (0%) | 0% | 161.0 | 2,014,360 | Common Stock |
| Steven M. Paul | None | Sale of securities on an exchange or to another person at price $ 161.02 per share. | 15 Feb 2019 | 12,519 | 111,385 (0%) | 0% | 161.0 | 2,015,809 | Common Stock |
| Steven M. Paul | None | Gift of securities by or to the insider at price $ 0.00 per share. | 15 Feb 2019 | 241,695 | 241,695 (0%) | 0% | 0 | Common Stock | |
| Anne Marie Cook | SVP, GC & Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2019 | 19,000 | 19,000 | - | - | Stock Option (Right to Buy) | |
| Jeffrey M. Jonas | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2019 | 50,000 | 50,000 | - | - | Stock Option (Right to Buy) | |
| Kimi Iguchi | CFO & Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2019 | 19,000 | 19,000 | - | - | Stock Option (Right to Buy) | |
| Stephen J. Kanes | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2019 | 19,000 | 19,000 | - | - | Stock Option (Right to Buy) | |
| Albert J. Robichaud | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2019 | 19,000 | 19,000 | - | - | Stock Option (Right to Buy) | |
| Michael Cloonan | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2019 | 24,500 | 24,500 | - | - | Stock Option (Right to Buy) | |
| Stephen J. Kanes | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 150.00 per share. | 08 Feb 2019 | 22,948 | 941 (0%) | 0% | 150 | 3,442,200 | Common Stock |
| James M. Frates | None | Sale of securities on an exchange or to another person at price $ 134.81 per share. | 23 Jan 2019 | 7,500 | 4,235 (0%) | 0% | 134.8 | 1,011,075 | Common Stock |
| James M. Frates | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 8.92 per share. | 23 Jan 2019 | 7,500 | 11,735 (0%) | 0% | 8.9 | 66,900 | Common Stock |
| James M. Frates | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Jan 2019 | 7,500 | 9,309 | - | - | Stock Option (Right to Buy) | |
| George Golumbeski | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jan 2019 | 20,000 | 20,000 | - | - | Stock Options (Right to buy) | |
| Elizabeth Barrett | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jan 2019 | 20,000 | 20,000 | - | - | Stock Options (Right to buy) | |
| Jeffrey M. Jonas | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Jan 2019 | 10,000 | 221,987 | - | - | Stock Option (Right to Buy) | |
| Jeffrey M. Jonas | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.45 per share. | 09 Jan 2019 | 10,000 | 62,115 (0%) | 0% | 0.5 | 4,500 | Common Stock |
| Geno J. Germano | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2019 | 878 | 878 | - | - | Stock Option (Right to Buy) | |
| Steven M. Paul | None | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Dec 2018 | 123,904 | 123,904 (0%) | 0% | 0 | Common Stock | |
| Steven M. Paul | None | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Dec 2018 | 121,035 | 514,472 (1%) | 0% | 0 | Common Stock | |
| Steven M. Paul | None | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Dec 2018 | 121,035 | 123,904 (0%) | 0% | 0 | Common Stock | |
| Steven M. Paul | None | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Dec 2018 | 123,904 | 0 (0%) | 0% | 0 | Common Stock | |
| Albert J. Robichaud | Chief Scientific Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Dec 2018 | 875 | 94,962 (0%) | 0% | 0 | Common Stock | |
| Anne Marie Cook | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Dec 2018 | 9,240 | 9,240 | - | - | Stock Option (Right to Buy) | |
| Jeffrey M. Jonas | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Dec 2018 | 23,100 | 23,100 | - | - | Stock Option (Right to Buy) | |
| Kimi Iguchi | CFO & Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Dec 2018 | 7,425 | 7,425 | - | - | Stock Option (Right to Buy) | |
| Stephen J. Kanes | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Dec 2018 | 6,600 | 6,600 | - | - | Stock Option (Right to Buy) | |
| Albert J. Robichaud | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Dec 2018 | 6,600 | 6,600 | - | - | Stock Option (Right to Buy) | |
| James M. Frates | None | Gift of securities by or to the insider at price $ 0.00 per share. | 22 Aug 2018 | 65 | 4,235 (0%) | 0% | 0 | Common Stock | |
| James M. Frates | None | Gift of securities by or to the insider at price $ 0.00 per share. | 22 Aug 2018 | 700 | 4,300 (0%) | 0% | 0 | Common Stock | |
| Kimi Iguchi | CFO & Treasurer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.45 per share. | 19 Jun 2018 | 800 | 26,826 (0%) | 0% | 0.5 | 360 | Common Stock |
| Kimi Iguchi | CFO & Treasurer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Jun 2018 | 800 | 67,949 | - | - | Stock Option (Right to Buy) | |
| James M. Frates | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2018 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Steven M. Paul | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2018 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Geno J. Germano | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2018 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Kevin P. Starr | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2018 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Michael F. Cola | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2018 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Asha Nayak | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2018 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| James M. Frates | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 May 2018 | 7,000 | 16,809 | - | - | Stock Option (Right to Buy) | |
| James M. Frates | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 8.92 per share. | 08 May 2018 | 7,000 | 12,000 (0%) | 0% | 8.9 | 62,440 | Common Stock |
| James M. Frates | None | Sale of securities on an exchange or to another person at price $ 154.00 per share. | 08 May 2018 | 7,000 | 5,000 (0%) | 0% | 154 | 1,078,000 | Common Stock |
| Kimi Iguchi | CFO & Treasurer | Sale of securities on an exchange or to another person at price $ 143.09 per share. | 26 Apr 2018 | 3,207 | 35,038 (0%) | 0% | 143.1 | 458,890 | Common Stock |
| Kimi Iguchi | CFO & Treasurer | Sale of securities on an exchange or to another person at price $ 141.21 per share. | 26 Apr 2018 | 100 | 38,245 (0%) | 0% | 141.2 | 14,121 | Common Stock |
| Kimi Iguchi | CFO & Treasurer | Sale of securities on an exchange or to another person at price $ 143.90 per share. | 26 Apr 2018 | 3,300 | 31,738 (0%) | 0% | 143.9 | 474,870 | Common Stock |
| Kimi Iguchi | CFO & Treasurer | Sale of securities on an exchange or to another person at price $ 144.98 per share. | 26 Apr 2018 | 6,075 | 25,663 (0%) | 0% | 145.0 | 880,754 | Common Stock |
| Kimi Iguchi | CFO & Treasurer | Sale of securities on an exchange or to another person at price $ 145.80 per share. | 26 Apr 2018 | 100 | 25,563 (0%) | 0% | 145.8 | 14,580 | Common Stock |
| Kimi Iguchi | CFO & Treasurer | Sale of securities on an exchange or to another person at price $ 141.26 per share. | 23 Apr 2018 | 2,300 | 39,245 (0%) | 0% | 141.3 | 324,898 | Common Stock |
| Kimi Iguchi | CFO & Treasurer | Sale of securities on an exchange or to another person at price $ 142.69 per share. | 23 Apr 2018 | 900 | 38,345 (0%) | 0% | 142.7 | 128,421 | Common Stock |
| Kimi Iguchi | CFO & Treasurer | Sale of securities on an exchange or to another person at price $ 142.84 per share. | 23 Apr 2018 | 2,999 | 63,499 (0%) | 0% | 142.8 | 428,377 | Common Stock |
| Kimi Iguchi | CFO & Treasurer | Sale of securities on an exchange or to another person at price $ 143.90 per share. | 23 Apr 2018 | 4,700 | 58,799 (0%) | 0% | 143.9 | 676,330 | Common Stock |
| Kimi Iguchi | CFO & Treasurer | Sale of securities on an exchange or to another person at price $ 144.71 per share. | 23 Apr 2018 | 2,601 | 56,198 (0%) | 0% | 144.7 | 376,391 | Common Stock |
| Kimi Iguchi | CFO & Treasurer | Sale of securities on an exchange or to another person at price $ 145.58 per share. | 23 Apr 2018 | 700 | 55,498 (0%) | 0% | 145.6 | 101,906 | Common Stock |
| Kimi Iguchi | CFO & Treasurer | Sale of securities on an exchange or to another person at price $ 149.54 per share. | 23 Apr 2018 | 635 | 54,863 (0%) | 0% | 149.5 | 94,958 | Common Stock |
| Kimi Iguchi | CFO & Treasurer | Sale of securities on an exchange or to another person at price $ 150.68 per share. | 23 Apr 2018 | 500 | 54,363 (0%) | 0% | 150.7 | 75,340 | Common Stock |
| Kimi Iguchi | CFO & Treasurer | Sale of securities on an exchange or to another person at price $ 141.51 per share. | 23 Apr 2018 | 2,500 | 51,863 (0%) | 0% | 141.5 | 353,775 | Common Stock |
| Kimi Iguchi | CFO & Treasurer | Sale of securities on an exchange or to another person at price $ 142.50 per share. | 23 Apr 2018 | 900 | 50,963 (0%) | 0% | 142.5 | 128,250 | Common Stock |
| Kimi Iguchi | CFO & Treasurer | Sale of securities on an exchange or to another person at price $ 144.06 per share. | 23 Apr 2018 | 500 | 50,463 (0%) | 0% | 144.1 | 72,030 | Common Stock |
| Kimi Iguchi | CFO & Treasurer | Sale of securities on an exchange or to another person at price $ 145.10 per share. | 23 Apr 2018 | 600 | 49,863 (0%) | 0% | 145.1 | 87,060 | Common Stock |
| Kimi Iguchi | CFO & Treasurer | Sale of securities on an exchange or to another person at price $ 146.14 per share. | 23 Apr 2018 | 500 | 49,363 (0%) | 0% | 146.1 | 73,070 | Common Stock |
| Kimi Iguchi | CFO & Treasurer | Sale of securities on an exchange or to another person at price $ 140.38 per share. | 23 Apr 2018 | 7,818 | 41,545 (0%) | 0% | 140.4 | 1,097,491 | Common Stock |
| Kevin P. Starr | None | Sale of securities on an exchange or to another person at price $ 169.25 per share. | 17 Apr 2018 | 35,000 | 326,817 (0%) | 0% | 169.2 | 5,923,600 | Common Stock |
| Kevin P. Starr | None | Sale of securities on an exchange or to another person at price $ 168.28 per share. | 17 Apr 2018 | 24,000 | 302,817 (0%) | 0% | 168.3 | 4,038,650 | Common Stock |
| Anne Marie Cook | Senior VP, General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Apr 2018 | 31,500 | 31,500 | - | - | Stock Option (Right to Buy) | |
| Jeffrey M. Jonas | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Apr 2018 | 90,000 | 90,000 | - | - | Stock Option (Right to Buy) | |
| Kimi Iguchi | CFO & Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Apr 2018 | 31,500 | 31,500 | - | - | Stock Option (Right to Buy) | |
| Stephen J. Kanes | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Apr 2018 | 27,000 | 27,000 | - | - | Stock Option (Right to Buy) | |
| Albert J. Robichaud | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Apr 2018 | 31,500 | 31,500 | - | - | Stock Option (Right to Buy) | |
| Michael Cloonan | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Apr 2018 | 36,000 | 36,000 | - | - | Stock Option (Right to Buy) | |
| Steven M. Paul | None | Sale of securities on an exchange or to another person at price $ 172.00 per share. | 06 Mar 2018 | 58,139 | 632,712 (1%) | 0% | 172 | 9,999,908 | Common Stock |
| Kevin P. Starr | None | Other type of transaction at price $ 0.00 per share. | 16 Feb 2018 | 510,554 | 37,362 (0%) | 1% | 0 | Common Stock | |
| Stephen J. Kanes | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 173.09 per share. | 10 Jan 2018 | 1,200 | 43,948 (0%) | 0% | 173.1 | 207,708 | Common Stock |
| Stephen J. Kanes | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 175.03 per share. | 10 Jan 2018 | 2,461 | 39,287 (0%) | 0% | 175.0 | 430,749 | Common Stock |
| Stephen J. Kanes | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 176.53 per share. | 10 Jan 2018 | 11,057 | 28,230 (0%) | 0% | 176.5 | 1,951,892 | Common Stock |
| Stephen J. Kanes | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 177.48 per share. | 10 Jan 2018 | 9,100 | 19,130 (0%) | 0% | 177.5 | 1,615,068 | Common Stock |
| Stephen J. Kanes | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 178.33 per share. | 10 Jan 2018 | 6,923 | 12,207 (0%) | 0% | 178.3 | 1,234,579 | Common Stock |
| Stephen J. Kanes | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 179.61 per share. | 10 Jan 2018 | 7,859 | 4,348 (0%) | 0% | 179.6 | 1,411,555 | Common Stock |
| Stephen J. Kanes | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 180.11 per share. | 10 Jan 2018 | 1,400 | 2,948 (0%) | 0% | 180.1 | 252,154 | Common Stock |
| Stephen J. Kanes | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.45 per share. | 10 Jan 2018 | 20,000 | 22,948 (0%) | 0% | 0.5 | 9,000 | Common Stock |
| Stephen J. Kanes | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jan 2018 | 20,000 | 111,432 | - | - | Stock Option (Right to Buy) | |
| Stephen J. Kanes | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 170.67 per share. | 10 Jan 2018 | 600 | 46,348 (0%) | 0% | 170.7 | 102,402 | Common Stock |
| Stephen J. Kanes | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 171.80 per share. | 10 Jan 2018 | 1,200 | 45,148 (0%) | 0% | 171.8 | 206,160 | Common Stock |
| Stephen J. Kanes | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 174.35 per share. | 10 Jan 2018 | 2,200 | 41,748 (0%) | 0% | 174.4 | 383,570 | Common Stock |
| Jeffrey M. Jonas | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.45 per share. | 26 Dec 2017 | 50,000 | 51,226 (0%) | 0% | 0.5 | 22,500 | Common Stock |
| Jeffrey M. Jonas | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Dec 2017 | 50,000 | 232,552 | - | - | Stock Option (Right to Buy) | |
| Jeffrey M. Jonas | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 155.00 per share. | 21 Dec 2017 | 12,753 | 1,226 (0%) | 0% | 155 | 1,976,715 | Common Stock |
| Jeffrey M. Jonas | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.45 per share. | 21 Dec 2017 | 12,753 | 13,979 (0%) | 0% | 0.5 | 5,739 | Common Stock |
| Jeffrey M. Jonas | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 162.59 per share. | 21 Dec 2017 | 599 | 1,226 (0%) | 0% | 162.6 | 97,391 | Common Stock |
| Jeffrey M. Jonas | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 162.08 per share. | 21 Dec 2017 | 5,000 | 1,825 (0%) | 0% | 162.1 | 810,400 | Common Stock |
| Jeffrey M. Jonas | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 160.36 per share. | 21 Dec 2017 | 13,049 | 6,825 (0%) | 0% | 160.4 | 2,092,538 | Common Stock |
| Jeffrey M. Jonas | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 159.53 per share. | 21 Dec 2017 | 22,334 | 19,874 (0%) | 0% | 159.5 | 3,562,943 | Common Stock |
| Jeffrey M. Jonas | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 158.21 per share. | 21 Dec 2017 | 33,301 | 42,208 (0%) | 0% | 158.2 | 5,268,551 | Common Stock |
| Jeffrey M. Jonas | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 157.48 per share. | 21 Dec 2017 | 27,152 | 75,509 (0%) | 0% | 157.5 | 4,275,897 | Common Stock |
| Jeffrey M. Jonas | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 156.55 per share. | 21 Dec 2017 | 71,823 | 102,661 (0%) | 0% | 156.6 | 11,243,891 | Common Stock |
| Jeffrey M. Jonas | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 155.48 per share. | 21 Dec 2017 | 36,989 | 174,484 (0%) | 0% | 155.5 | 5,751,050 | Common Stock |
| Jeffrey M. Jonas | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Dec 2017 | 110,247 | 295,305 | - | - | Stock Option (Right to Buy) | |
| Jeffrey M. Jonas | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Dec 2017 | 12,753 | 282,552 | - | - | Stock Option (Right to Buy) | |
| Jeffrey M. Jonas | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.45 per share. | 21 Dec 2017 | 110,247 | 211,473 (0%) | 0% | 0.4 | 49,611 | Common Stock |
| Albert J. Robichaud | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 156.31 per share. | 14 Dec 2017 | 1,500 | 152,759 (0%) | 0% | 156.3 | 234,465 | Common Stock |
| Albert J. Robichaud | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 157.27 per share. | 14 Dec 2017 | 3,700 | 149,059 (0%) | 0% | 157.3 | 581,899 | Common Stock |
| Albert J. Robichaud | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 163.93 per share. | 14 Dec 2017 | 1,021 | 94,259 (0%) | 0% | 163.9 | 167,373 | Common Stock |
| Albert J. Robichaud | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 162.21 per share. | 14 Dec 2017 | 700 | 95,280 (0%) | 0% | 162.2 | 113,547 | Common Stock |
| Albert J. Robichaud | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 161.40 per share. | 14 Dec 2017 | 6,187 | 95,980 (0%) | 0% | 161.4 | 998,582 | Common Stock |
| Albert J. Robichaud | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 160.12 per share. | 14 Dec 2017 | 21,410 | 102,167 (0%) | 0% | 160.1 | 3,428,169 | Common Stock |
| Albert J. Robichaud | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 159.46 per share. | 14 Dec 2017 | 8,734 | 123,577 (0%) | 0% | 159.5 | 1,392,724 | Common Stock |
| Albert J. Robichaud | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 158.18 per share. | 14 Dec 2017 | 16,748 | 132,311 (0%) | 0% | 158.2 | 2,649,199 | Common Stock |
| Asha Nayak | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Nov 2017 | 20,883 | 20,883 | - | - | Stock Options (Right to buy) | |
| Kevin P. Starr | None | Other type of transaction at price $ 0.00 per share. | 27 Sep 2017 | 545,000 | 547,916 (1%) | 1% | 0 | Common Stock | |
| Kevin P. Starr | None | Other type of transaction at price $ 0.00 per share. | 18 Jul 2017 | 800,000 | 1,092,916 (2%) | 2% | 0 | Common Stock | |
| James M. Frates | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2017 | 14,000 | 14,000 | - | - | Stock Option (Right to Buy) | |
| Steven M. Paul | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2017 | 14,000 | 14,000 | - | - | Stock Option (Right to Buy) | |
| Geno J. Germano | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2017 | 14,000 | 14,000 | - | - | Stock Option (Right to Buy) | |
| Kevin P. Starr | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2017 | 14,000 | 14,000 | - | - | Stock Option (Right to Buy) | |
| Michael F. Cola | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2017 | 14,000 | 14,000 | - | - | Stock Option (Right to Buy) | |
| Michael Cloonan | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 May 2017 | 185,000 | 185,000 | - | - | Stock Option (Right to Buy) | |
| Anne Marie Cook | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Feb 2017 | 56,000 | 56,000 | - | - | Stock Option (Right to Buy) | |
| Jeffrey M. Jonas | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Feb 2017 | 140,000 | 140,000 | - | - | Stock Option (Right to Buy) | |
| Kimi Iguchi | CFO & Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Feb 2017 | 45,000 | 45,000 | - | - | Stock Option (Right to Buy) | |
| Stephen J. Kanes | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Feb 2017 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| Albert J. Robichaud | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Feb 2017 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| Thomas Anderson | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Feb 2017 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| Steven M. Paul | None | Other type of transaction at price $ 3.15 per share. | 31 Jan 2017 | 2,174 | 690,851 (1%) | 0% | 3.1 | 6,848 | Common Stock |
| Kevin P. Starr | None | Other type of transaction at price $ 0.00 per share. | 23 Jan 2017 | 1,000,000 | 1,892,916 (5%) | 2% | 0 | Common Stock | |
| Kimi Iguchi | CFO, Secretary and Treasurer | Sale of securities on an exchange or to another person at price $ 53.92 per share. | 13 Jan 2017 | 10,000 | 66,498 (0%) | 0% | 53.9 | 539,200 | Common Stock |
| Thomas Anderson | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Dec 2016 | 1,900 | 165,138 | - | - | Stock Option (Right to Buy) | |
| Thomas Anderson | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Dec 2016 | 1,900 | 1,900 | - | - | Common Stock | |
| Thomas Anderson | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 15 Dec 2016 | 346 | 1,554 | - | - | Common Stock | |
| Kimi Iguchi | CFO, Secretary and Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Dec 2016 | 14,400 | 68,000 | - | - | Stock Option (Right to Buy) | |
| Anne Marie Cook | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Dec 2016 | 10,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| Jeffrey M. Jonas | Director, See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Dec 2016 | 43,200 | 324,000 | - | - | Stock Option (Right to Buy) | |
| Stephen J. Kanes | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Dec 2016 | 14,400 | 68,000 | - | - | Stock Option (Right to Buy) | |
| Albert J. Robichaud | Chief Scientific Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 08 Dec 2016 | 250 | 154,759 | - | - | Common Stock | |
| Albert J. Robichaud | Chief Scientific Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 08 Dec 2016 | 250 | 155,009 | - | - | Common Stock | |
| Albert J. Robichaud | Chief Scientific Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 08 Dec 2016 | 250 | 155,259 | - | - | Common Stock | |
| Albert J. Robichaud | Chief Scientific Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 08 Dec 2016 | 250 | 154,259 | - | - | Common Stock | |
| Albert J. Robichaud | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Dec 2016 | 10,800 | 51,000 | - | - | Stock Option (Right to Buy) | |
| Albert J. Robichaud | Chief Scientific Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 08 Dec 2016 | 250 | 154,509 | - | - | Common Stock | |
| Thomas Anderson | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Dec 2016 | 12,600 | 59,500 | - | - | Stock Option (Right to Buy) | |
| Kimi Iguchi | CFO, Secretary and Treasurer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 17 Nov 2016 | 4,000 | 75,739 | - | - | Common Stock | |
| Thomas Anderson | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Nov 2016 | 10,000 | 167,038 | - | - | Stock Option (Right to Buy) | |
| Thomas Anderson | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Nov 2016 | 10,000 | 10,000 | - | - | Common Stock | |
| Thomas Anderson | See Remarks | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 15 Nov 2016 | 10,000 | 0 | - | - | Common Stock | |
| Kimi Iguchi | CFO, Secretary and Treasurer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 11 Nov 2016 | 1,500 | 79,739 | - | - | Common Stock | |
| Albert J. Robichaud | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Oct 2016 | 15,287 | 155,509 | - | - | Common Stock | |
| Albert J. Robichaud | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Oct 2016 | 15,287 | 6,935 | - | - | Stock Option (Right to Buy) | |
| Kimi Iguchi | CFO, Secretary and Treasurer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 07 Sep 2016 | 2,500 | 81,239 | - | - | Common Stock | |
| Mark J. Levin | Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 19 Aug 2016 | 1,000,000 | 2,892,916 | - | - | Common Stock | |
| Kevin P. Starr | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 19 Aug 2016 | 1,000,000 | 2,892,916 | - | - | Common Stock | |
| Geno J. Germano | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jul 2016 | 20,883 | 20,883 | - | - | Stock Options (Right to buy) | |
| Kimi Iguchi | CFO, Secretary and Treasurer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 12 Jul 2016 | 5,000 | 83,739 | - | - | Common Stock | |
| Albert J. Robichaud | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 12 Jul 2016 | 22,000 | 140,222 | - | - | Common Stock | |
| James M. Frates | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jun 2016 | 13,922 | 13,922 | - | - | Stock Options (Right to buy) | |
| Howard H. Pien | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jun 2016 | 13,922 | 13,922 | - | - | Stock Options (Right to buy) | |
| Kevin P. Starr | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jun 2016 | 13,922 | 13,922 | - | - | Stock Options (Right to buy) | |
| Michael F. Cola | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jun 2016 | 13,922 | 13,922 | - | - | Stock Options (Right to buy) | |
| Steven M. Paul | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jun 2016 | 13,922 | 13,922 | - | - | Stock Options (Right to buy) | |
| Mark J. Levin | Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 16 May 2016 | 850,000 | 3,892,916 | - | - | Common Stock | |
| Kevin P. Starr | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 16 May 2016 | 850,000 | 3,892,916 | - | - | Common Stock | |
| Stephen J. Kanes | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Apr 2016 | 21,000 | 46,948 | - | - | Common Stock | |
| Stephen J. Kanes | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 19 Apr 2016 | 21,000 | 25,948 | - | - | Common Stock | |
| Stephen J. Kanes | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Apr 2016 | 21,000 | 112,100 | - | - | Stock Option (Right to Buy) | |
| Steven M. Paul | None | Gift of securities by or to the insider at price $ 0.00 per share. | 23 Feb 2016 | 847 | 681,956 | - | - | Common Stock | |
| Steven M. Paul | None | Gift of securities by or to the insider at price $ 0.00 per share. | 23 Feb 2016 | 847 | 678,992 | - | - | Common Stock | |
| Steven M. Paul | None | Gift of securities by or to the insider at price $ 0.00 per share. | 23 Feb 2016 | 847 | 682,803 | - | - | Common Stock | |
| Steven M. Paul | None | Gift of securities by or to the insider at price $ 0.00 per share. | 23 Feb 2016 | 847 | 679,839 | - | - | Common Stock | |
| Steven M. Paul | None | Gift of securities by or to the insider at price $ 0.00 per share. | 23 Feb 2016 | 847 | 681,109 | - | - | Common Stock | |
| Steven M. Paul | None | Gift of securities by or to the insider at price $ 0.00 per share. | 23 Feb 2016 | 423 | 678,569 | - | - | Common Stock | |
| Steven M. Paul | None | Gift of securities by or to the insider at price $ 0.00 per share. | 23 Feb 2016 | 423 | 680,686 | - | - | Common Stock | |
| Kimi Iguchi | CFO, Secretary and Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Feb 2016 | 15,000 | 15,000 | - | - | Stock Option (Right to Buy) | |
| Anne Marie Cook | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Feb 2016 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| Jeffrey M. Jonas | Director, See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Feb 2016 | 60,000 | 60,000 | - | - | Stock Option (Right to Buy) | |
| Stephen J. Kanes | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Feb 2016 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Albert J. Robichaud | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Feb 2016 | 25,000 | 25,000 | - | - | Stock Option (Right to Buy) | |
| Thomas Anderson | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Feb 2016 | 22,500 | 22,500 | - | - | Stock Option (Right to Buy) | |
| Albert J. Robichaud | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 25 Jan 2016 | 20,000 | 162,222 | - | - | Common Stock | |
| Kimi Iguchi | CFO, Secretary and Treasurer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Jan 2016 | 4,000 | 88,739 | - | - | Common Stock | |
| Kimi Iguchi | CFO, Secretary and Treasurer | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 07 Jan 2016 | 176 | 84,739 | - | - | Common Stock | |
| Kimi Iguchi | CFO, Secretary and Treasurer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Jan 2016 | 4,000 | 61,495 | - | - | Stock Option (Right to Buy) | |
| Jeffrey M. Jonas | Director, See Remarks | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 07 Jan 2016 | 226 | 81,226 | - | - | Common Stock | |
| Jeffrey M. Jonas | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Jan 2016 | 20,000 | 101,226 | - | - | Common Stock | |
| Jeffrey M. Jonas | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Jan 2016 | 20,000 | 400,360 | - | - | Stock Option (Right to Buy) | |
| Mark J. Levin | Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 12 Nov 2015 | 15,986 | 65,226 | - | - | Common Stock | |
| Mark J. Levin | Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 12 Nov 2015 | 109,832 | 0 | - | - | Common Stock | |
| Mark J. Levin | Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 12 Nov 2015 | 109,832 | 109,832 | - | - | Common Stock |